1990    B .S., Ccum laude,  Santa Clara University, Santa Clara, CA
1995    M.D., High honors,  University of Nebraska Medical Center (UNMC), Omaha, NE
1998    Resident, Internal Medicine UNMC, Omaha, NE
1999    Chief Resident, Internal Medicine UNMC, Omaha, NE
2001    M.S.P.H., Epidemiology,  University of Alabama at Birmingham, Birmingham, AL
2001    Fellow in Rheumatology University of Alabama at Birmingham, Birmingham, AL
2002    Participant, NIH (K-30) Clinical University of Alabama at Research Training Program Birmingham,
            Birmingham, AL

Current Hospital and Academic Appointments:
Associate Member, Eppley Institute, Cancer Prevention and Control Program
Faculty, University of Nebraska Graduate College
Director / Investigator, Nebraska Arthritis Outcomes Research Center (NAORC)
Director, Omaha VA RA/DMARD Clinic
Associate Professor, UNMC and Omaha VAMC, Omaha, NE

University of Nebraska Medical Center
Omaha VA Medical Center


Biographical Sketch:
Dr. Mikuls currently serves on the U.S. FDA Arthritis Advisory Committee and chairs the American College of Rheumatology (ACR) Clinical Guidelines Subcommittee.   He has served on numerous other committees and national grant review study sections, including those for the VA, Arthritis Foundation, NIH, and the ACR.  He is co-director of the Nebraska Arthritis Outcomes Research Center.  Dr. Mikuls’ research efforts are focused on the epidemiology and health outcomes in rheumatoid arthritis (RA) and gout.  Ongoing projects involve the investigation of genetic and environmental determinants in RA disease expression in addition to exploring the role of complex gene-environment interactions in understudied populations (African Americans and male veterans).  He receives funding from the NIH, Veterans Affairs (VA), and the American College of Rheumatology REF Within Our Reach campaign. 

Research Interests/Current Research:
Outcomes and epidemiology of rheumatoid arthritis
Health outcomes and quality of care in gout

Recent NDB research

England BR, Sayles H, Mikuls TR, Johnson DS, Michaud K. Validation of the Rheumatic Disease Comorbidity Index. Arthritis Care Res (Hoboken) 2014 Sep 3. doi: 10.1002/acr.22456. PubMed link
Cannon GW, DuVall SL, Haroldsen CL, Caplan L, Curtis JR, Michaud K, et al. Persistence and Dose Escalation of Tumor Necrosis Factor Inhibitors in US Veterans with Rheumatoid Arthritis.J Rheumatol. 2014 Aug 15. pii: jrheum.140164. PubMed link
Kerr G, Aujero M, Richards J, Sayles H, Davis L, Cannon G, Caplan L, Michaud K, Mikuls T. Associations of hydroxychloroquine use with lipid profiles in rheumatoid arthritis: Pharmacologic implications. Arthritis Care Res (Hoboken). 2014 Apr 1. doi: 10.1002/acr.22341. PubMed link
Sokolove J, Johnson DS, Lahey LJ, Wagner CA, Cheng D, Thiele GM, Michaud K, et al. Rheumatoid factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in rheumatoid arthritis. Arthritis Rheumatol. 2014 Apr;66(4):813-21. doi: 10.1002/art.38307. PubMed link
Michaud K, Fehringer EV, Garvin K, O'Dell JR, Mikuls TR. Rheumatoid arthritis patients are not at increased risk for 30-day cardiovascular events, infections, or mortality after total joint arthroplasty. Arthritis Res Ther. 2013;15(6):R195. PubMed link
Davis ML, Michaud K, Sayles H, Conn DL, Moreland LW, Bridges SL Jr, Mikuls TR. Associations of alcohol use with radiographic disease progression in African Americans with recent-onset rheumatoid arthritis. Journal of Rheumatology. 2013:40(9):1498-504. PubMed link
Demoruelle MK, Parish MC, Derber LA, Kolfenbach JR, Hughes-Austin JM, Weisman MH. Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease. Arthritis Rheum. 2013 Sep;65(9):2243-52. doi: 10.1002/art.38017. PubMed link
Young KA, Deane KD, Derber LA, Hughes-Austin JM, Wagner CA, Sokolove J. Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis. Arthritis Rheum. 2013 Aug;65(8):1995-2004. doi: 10.1002/art.38022. PubMed link
Mikuls TR, Padala PR, Sayles HR, Yu F, Michaud K, Caplan L. et al. Prospective study of posttraumatic stress disorder and disease activity outcomes in US veterans with rheumatoid arthritis. Arthritis Care and Research. 2013:Vol. 65(2):227-3 PubMed link
Carter MJ, Mikuls TR, Nayak S, Fehringer EV, Michaud K. Meta-analysis: The impact of total shoulder arthroplasty on generic and shoulder-specific health-related quality of life measures. Journal of Bone and Joint Surgery. 2012:Vol.94(17)e127 1-9 PubMed link